Discovering and Developing Molecules with Optimal Drug-Like by Allen C Templeton,Stephen R. Byrn,Roy J Haskell,Thomas E.

By Allen C Templeton,Stephen R. Byrn,Roy J Haskell,Thomas E. Prisinzano

This authoritative quantity offers a modern view at the most recent study in molecules with optimum drug-like homes. it's a necessary resource to entry present most sensible practices in addition to new learn strategies and techniques. Written by means of prime scientists of their fields, the textual content contains fourteen chapters with an underlying subject matter of early collaborative possibilities among pharmaceutical and discovery sciences. The ebook explores the sensible realities of acting actual pharmaceutical and biopharmaceutical learn within the context of drug discovery with brief timelines and occasional compound availability. Chapters conceal thoughts and strategies to permit discovery in addition to predictive techniques to set up, comprehend and converse dangers in early improvement. It additionally examines the detection, characterization, and review of hazards at the sturdy country houses of complicated discovery and early improvement applicants, highlighting the hyperlink among reliable kingdom houses and significant improvement parameters equivalent to solubility and balance. ultimate chapters middle on strategies to enhance molecular solubilization and forestall precipitation, with rather emphasis on linking physiochemical houses of molecules to formula choice in preclinical and scientific settings.

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